Shtip has left numerous traces in history.
The name Astibo was mentioned for the first time by the ancient chronicler Polyenvo (3rd century BC). He wrote that in Astibo (today's Bregalnica) ritual bathing of the Peon kings was performed. Astibo is mentioned again in the Tabula Peutinghemiana (ancient map from the 4th century) as a settlement on the road to Stobi - Pautalia.

Historians locate remains of Astibo in the area of today's old part of the city, on the eastern slopes of the Isar hill and the Old Konak, Tuzliai Gorno Maalo sites. Today, from the ancient architecture of the city, the remains of the city aqueduct in the Qemer area, through which the city was supplied with clean water, have been partially preserved. The settlement existed in the late ancient and early Byzantine periods, probably under the name Stipeon, and in the Middle Ages the settlement received the name Shtip.

Textiles and leather
The municipality of Shtip is known as an industrial region with developed industrial branches, but with a particularly developed textile and leather industry. There are many fashion confections operating in the region, among which a few stand out due to the profitability and importance of the brands: Albatross, Kit-Go, Modena, Mavis, Maxima, Grazia, Beas-S, Britex, Shtipko, Shtip-tex, Vivendi, Milano, Escada and many other.